Cbs c699t rs234706 treatment 94 reduced risk of cleft lip / palate rs234706 G/G: Common in clinvar CBS 699 rs234706 BAD SIDE EFFECTS * CBS 699rs234706 The [CBS C699T] SNP can UP-REGULATE the speed of the CBS enzyme’s function at 10-15 x the There have also been reports on the potential relationship of two silent polymorphisms of the CBS gene (C699T and C1080T) and the occurrence of mild HHcy. CBS C699T rs234706 GG -/- CBS A360A rs1801181 Any such diagnosis and/or treatment/ therapeutic plan rs4920037 AG A CBS C19150T +/-rs234706 AG A CBS C699T +/-rs4880 AG A SOD2 A16V +/-rs1799895 CC G SOD3 Ex3-631C>G -/-rs1695 AA G GSTP1 Ile105Val -/-rs1138272 CC T GSTP1 A114V -/-rs1050828 C T G6PD G202A -/- rs234706 A/A: 0. 05 (P = 0. 5%) in the autism patients, CBS C699T rs234706 AA +/+ Detox: Gene & Variation rsID Alleles Result CYP1A1*2C A4889G rs1048943 TT -/-CYP1A1 m3 T3205C rs4986883 TT -/- It took me about three months to treat CBS. The 3rd column is the risk allele, the fourth column is my alleles. I react much more to sulfites than sulfur. 12 and 67. . 26–0. *540G>A) in exon 17 of another unrelated MM subject. The frequency distribution of mutant and compound genotypes allele (T/T and C/T+T/T) of CBS C699T (rs234706) were (27. 51 reduced risk of non-hodgkin lymphoma. October 2, 2018 at 9:25 pm - Reply. No significant association was found between Abstract Folate, methionine and trans-sulfuration pathways and enzymes` are playing an important role synthetase (CBS) is a key enzyme of these As far as treatment, I’ve started with SHMT spray (1 week ago) and every few days take one capsule of the Ultimate B Complex in addition to a trace mineral complex supplement (Seeking Health brand). 4 Cystathionine β-synthase. Taurine and Cysteine could help normalize RS234706 CBS C699T -/- GG RS1801181 CBS A360A +/+ AA. 63-1. Vitamin B6. Gene SNP Alleles What it means Diet & Lifestyle CBS C699T (rs234706) Plasma B6: Adults: 2. If you have any questions about our services or CBS: rs1801181 CBS (C699T): rs234706 COMT: rs4633, rs4680 DHFR: rs70991108 FUT2: rs601338 GSS: rs6088659 MAOA: rs6323 MAOB: rs1799836 MTHFD1: rs2236225 or accepting treatment, you confirm that you are the individual being tested, and that you are over 18 years old. The purpose of this enzyme is to take a substance called homocysteine, with the help of Vitamin B6, and turn the homocysteine into other substances. 4) and 0. Nutritional Support. org Page: 2 of 6. For a very good overview on CBS up-regulation via C699T (the gene with the most data), take a look at this article You can look at many different “spots” (SNPs) on the DNA to help assess your CBS variant, but the C699T SNP at rs234706 appears to be the most studied. The rs594445 C>A polymorphism in MOCOS , His703Asn, might modify enzyme activity that lead to reduce metabolic capacity of xanthine dehydrogenase (XDH) and aldehyde For example on a common panel of SNPs the CBS mutations that are Faster C699T; A360A; N212N versus Slower C19150T; A13637G need to be looked at. 94 reduced risk of cleft lip / palate rs234706 G/G: Common in clinvar Help me understand my mutations (COMT, MTHFR, VDR, CBS) - posted in Biomarkers & Genes: Here is the list from Genetic Genie with preserved coloring from the output: Gene & Variation rsID Alleles Result COMT V158M rs4680 AA +/+ COMT H62H rs4633 TT +/+ COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CC -/- VDR Taq rs731236 AA +/+ MAO A In the process of methylation, the Cystathionine Beta Synthase (CBS) genes (CBSA13637G, CBS C19150T, CBS C699T and CBS A360A ) produces the cystathionine beta synthase enzyme. 0. Certain mushrooms and herbs. If the treatment for COMT is universal regardless of your status, why get tested? ++ is prescribed the same treatment CBS C699T rs234706 GG -/-CBS A360A rs1801181 AG +/-CBS N212N rs2298758 GG -/-SHMT1 C1420T rs1979277 This information is not intended for the diagnosis, treatment or cure of disease. However, I have High whole blood homocysteine levels. The CBS enzyme reduces homocysteine to an intermediate (cysteine) that eventually can become These products are not intended to diagnose, treat, cure or prevent any disease. Dr. Posted 10/31/2016 11:56 AM (GMT -5) HealingWell. He is a recognized authority in the field of integrative cancer research and the treatment of chronic diseases, genomic conditions, and auto-immune and Sep 26, 2013 · CBS C699T rs234706 GG -/-CBS A360A rs1801181 GG -/-CBS N212N rs2298758 GG -/-SHMT1 C1420T rs1979277 AG +/-23andme Genova detoxigenomics Treatment for SOD2–get the methylation cycle working so you can raise glutathione. Messages 15,786. Help with DNA Results CBS C699T rs234706 AG CBS A360A rs1801181 GG CBS N212N rs2298758 GG SHMT1 C1420T rs1979277 GG Thanks Raymond #1 Jul 26, 2013; V. You have MTR and one MTRR, which is B12 intake and recycling. CBS defects are actually the enzyme working too fast. ? is C699T AG +- an ammonia issue at all or is it only C699T AA ++ ? rs2851391 CBS A13637G CT +/- rs1801181 CBS A360A AG +/- rs706209 CBS C*351T AG +/- rs4920037 CBS C19150T AG +/- rs234706 CBS C699T AG +/- rs12613 CBS CBS C699T rs234706 GG -/-CBS A360A rs1801181 GG -/-CBS N212N rs2298758 GG -/-SHMT1 C1420T rs1979277 GG -/-Thanks so much ! Audrey #1 Nov 7, 2013; Critterina Symptoms and Treatments. (Also on the Phoenix rising forum we've discussed Extra Energy Enzymes Dec 3, 2024 · CBS: Balances sulfur metabolism, impacting neurotransmitter levels. Those two would be GST and SOD. 96) with **CBS C699T rs234706 [fast] BAD SIDE EFFECTS ** *** CBS C699T rs234706** The Cystathionine Beta Synthase [CBS] C699T SNP can UP-REGULATE the **CBS 699 rs234706 [fast] BAD SIDE EFFECTS ** * CBS 699rs234706 The Cystathionine Beta Synthase [CBS C699T] SNP can UP-REGULATE the speed of the Obviously I have CBS rs234706 homozygous. Valentijn Senior Member. You reported inflammatory bowel disease. of rs234706 CBS C699T rs234706 AG +/-CBS A360A rs1801181 GG -/-CBS N212N rs2298758 GG -/-SHMT1 C1420T rs1979277 AG +/-Before getting started: Understanding the basics This information is not intended for the diagnosis, treatment or cure of disease. 1c shows PCR products of a 68bp insertion polymorphism (rs72058776) preceding exon 10 in a panel of 16 CBS:cystathionine beta-synthase [Gene - OMIM - HGNC] Variant type: single nucleotide variant Cytogenetic location: 21q22. After that things will start getting better unless you eat a lot of folic acid rich foods. MAO-A R297R MAO-A (Monoamine oxidase A) is a So someone seems to have reasoned that because one version of C699T is faster than the other versions, and Down's Syndrome is a potentially bad upregulation, and hacked mutant yeast is an upregulation, the C699T upregulation must somehow cause the same effect as hacking up the entire CBS gene in a mutant yeast and the elevated sulfur of Down's CBS C699T rs234706 AA +/+ Poor detox pathways (RED) CYP1A2 164A>C rs762551 CC +/+ CYP1B1 L432V rs1056836 GG +/+ Symptoms I still experience: daily fatigue despite adequate rest (going on 2 yrs now treatment), declined thank goodness! I do feel a lot better. 3 %Äåòåë§ó ÐÄÆ 4 0 obj /Length 5 0 R /Filter /FlateDecode >> stream x Í; ƒ0 EÑ>«x+ ìñ|˜> ]¨R#ä )„`‘ýcÝú螘q"ÀLfš2Ô 8àa¤ VñÆ Symptoms and Treatments. So I have problems having my Nov 22, 2013 · CBS C699T - rs234706; CBS A360A; CBS N212N; Click to expand rs1801181 - A360A rs2298758 - N212N Based on my notes, there's no research supporting that either has an impact, and there's research showing that A360A doesn't have any impact on homocysteine levels. Yasko has an all in one ACAT/BHMT supp that would be appropriate for you, but it's kind of expensive. 26 The CBS gene – cystathionine beta-synthase – codes for the CBS enzyme that acts within the transsulfuration pathway. 1-21. rs4920037 CBS C19150T A AA +/+ rs234706 CBS C699T A AA I also have a boatload of problems with COMT and am struggling to navigate everything. Ray B said: CBS C699T: rs234706: AG +/-CBS A360A: rs1801181: GG-/-CBS N212N: rs2298758: GG-/-SUOX S370S: not found: n/a: n/a: NOS3 D298E: not found: n/a: n/a: SHMT1 C1420T: rs1979277: This information is not intended for the CBS C699T rs234706 GG -/-SHMT1 C1420T rs1979277 GG -/-SOD2 A16V rs4880 GG +/+ Susan Rex Ryan. All comments/opinions are gratefully welcomed. com LLC does not provide medical advice, diagnosis, or treatment. The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. 016 and 0. 1a shows the sequences of a novel nonsense variant (c. 3 Genomic location: Chr21: 43065240 (on Assembly GRCh38) Chr21: 44485350 (on Assembly GRCh37) dbSNP: rs234706 NCBI 1000 Genomes Browser: rs234706 Molecular consequence: Polymorphism of genes encoding homocysteine metabolism–related enzymes and risk for cardiovascular disease. If you have two “G” alleles at that spot (one from each parent), that Utilizing variant allele frequency, disease prevalence and penetrance estimates, and inheritance mode, an automated score was calculated to assess if this variant is too We found significant associations with LDL-C and total-cholesterol levels for a synonymous SNP (rs234706) in the cystathionine beta-synthase (CBS) gene (p=1x10-5 and We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0. rs234706, also The SNP rs234706 or C699T in the CBS gene is perhaps the most widely investigated CBS SNP, and also the most controversial. Everything says that rs234706 specifically means upregulated CBS, and that unregulated leads to low homocysteine. CBS C699T rs234706 AA +/+ CBS A360A rs1801181 GG -/-CBS N212N rs2298758 GG -/-SHMT1 C1420T rs1979277 GG -/- So if this sounds like you, you'll need to test and treat your gut first, while taking supps for ACAT. CBS C699T (rs234706) association to CBS genotype The distribution frequency of the CBS C699T genotypes were, the wild type C/C found in (70 %) of the control cases where it was found in (47. He is a recognized authority in the field of integrative cancer research and the treatment of chronic diseases, genomic conditions, and auto-immune and CBS: rs1801181 CBS (C699T): rs234706 COMT: rs4633, rs4680 DHFR: rs70991108 FUT2: rs601338 GSS: rs6088659 MAOA: rs6323 MAOB: rs1799836 MTHFD1: rs2236225 activating a StrideDNA test, or accepting treatment, you confirm that you are the individual being tested, and that you are over 18 years old. The idea is to treat the gut at the same time as treating the SHMT SNP, which is supposed to have a better outcome than not treating them CBS C699T (rs234706) CTH rs1021737; Practical Tips to Lower Homocysteine. CBS A13637G rs2851391 T no call CBS A360A rs1801181 A no call CBS C19150T rs4920037 A GG -/- CBS C699T rs234706 A GG -/- Sep 9, 2013 · CBS C699T rs234706 AG +/-CBS A360A rs1801181 AG +/-SHMT1 C1420T rs1979277 AG +/- Click to expand I've deleted the -/- results and crossed out the SNPs which aren't relevant to gene functioning. New comments cannot be posted and votes cannot be cast. My plan has been a lower sulfur diet, molybdenum, methyl B12 and methylfolate, TMG, Magnesium Citrate at night and a multivitamin along with NDThyroid Estimates are graphed vertically for each variant. Symptoms and Treatments. Take Methylated B Vitamins: Use 5-MTHF and methylcobalamin for effective absorption. Hi, Tina. Increased responsiveness to homocysteine-lowering effects of folic acid. CBS C699T rs234706 GG CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. 25 gene variants were identified that were significant in any of the three tests with all significant at p ≤ 0. MTHFR Mutations First we'll look at a few of your MTHFR mutations. GlipiSOD. 003 and 0. Initial studies showed I have been slowly working through my two known defects, the CBS & the MTHFR A1298C, and have come across some controversy with the CBS C699T and ammonia. If there are variants in BDNF and GAD1, this can compound glutamate levels even more leading to many Three variants of CBS gene identified in the study. 043). An important question first, please. 5%) of the ASD cases. Messages 4,729 Jan 25, 2015 · Here are my CBS snps, which told me nothing. In that article I discussed how there appears to be two differing perspectives on the nature of CBS (cystathionine beta synthase) gene mutations: the literature’s contention of “down-regulated” CBS enzyme activity among carriers of certain mutations, and certain empirical, clinical observations of the opposite situation, specifically that We would like to show you a description here but the site won’t allow us. 5%) in the autism patients, (p disorders and GIT disorders (p=0. CT +/- > > AHCY-01 rs819147 CT +/- > > AHCY-02 rs819134 AG +/- > > AHCY-19 rs819171 CT +/- > > CBS C699T rs234706 GG -/- > > CBS A360A rs1801181 -- no call > > CBS N212N rs2298758 GG -/- > > SHMT1 C1420T CBS C699T rs234706 GG -/-CBS A360A rs1801181 GG -/-CBS N212N rs2298758 GG -/-SHMT1 C1420T rs1979277 "leaky gut genes". 05 and many at the much higher significance of I find so contradicting info about CBS C699T being or not an ammonia risk. The risk of SNPs was most significant under the additive model ( Table 4 ). Twelve SNPs (CBS-C699T, DHFR-c594+59del19, GST01-C428T, MTHFD-G1958A, MTHFR-C677T, MTHFR-A1298C, MTR-A2756G, MTRR-A66G, NFE2L2-ins1+C11108T, RFC1-G80A, TCN2-C776G, and TYMS-1494del6) in 503 DNA samples were simultaneously tested, and included 315 preterm births Sep 29, 2014 · CBS C699T rs234706 AG +/-CBS A360A rs1801181 AG +/-CYP1A2 164A>C rs762551 AC +/-CYP1B1 L432V rs1056836 GG +/+ CYP1B1 R48G rs10012 CG +/-CYP2D6 S486T rs1135840 CG +/-CYP2D6 2850C>T rs16947 AG +/- HealingWell. 001). If you have any questions about our services or CBS C699T (rs234706) CTH rs1021737 เคล็ดลับในการลดระดับโฮโมซิสเทอีน รับประทานอาหารที่อุดมด้วยโฟเลต Sep 28, 2024 · For example on a common panel of SNPs the CBS mutations that are Faster C699T; A360A; N212N versus Slower C19150T; A13637G need to be looked at. Methylation, B12, Glutathione, etc. 94 with one copy of the T allele (95% CI 0. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. 38, respectively). I have CBS C699T AG +- Hetero , CBS N212N AG +- Hetero As I understood this can cause to much ammonia. The low minor allele frequency for the 68bp insertion in CBS prevented calculation of a relative risk for two copies in the child’s genotype for CL/P and in the mother’s genotype for CPO. 7 ng/mL Serum homocysteine: CBS activity is inversely associated with homocysteine levels. Homozygous +/+ Heterozygous +/-Normal-/-Oh wow. CBS C699T rs234706 AG +/-CBS A360A rs1801181 GG -/-CBS N212N rs2298758 __ no call SHMT1 C1420T rs1979277 __ no call Name: Zachary McLeod Profile: Methylation Profile treatment or cure of disease. [PMID 18203168] We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0. 51 reduced risk of non-Hodgkin lymphoma. 50 (95% CI 0. 4. Relevant SNPs. Understand the role of genes like MTHFR, MTR, and BHMT in homocysteine regulation and heart health Kruger et al. Clearly the methylation cycle and genetic pathways are very important in your family. People with that gene can have gut problems. Trp54Stop) identified in exon 3 of an MM subject. The mutant allele T/T didn’t found in the control cases, while it presented in (27. I want to address my CBS but if I try to treat downregulated CBS when I'm upregulated, or Visa versa, I can make myself worse. People with a CBS mutation benefit from a low sulfur diet I took the 23andme test and have two copies of the C677T MTHFR mutated gene and am trying to treat two copies of CBS along with that. Methylated B vitamins (such as 5-MTHF and methylcobalamin) can help individuals with MTHFR variants maintain CBS: rs1801181 CBS (C699T): rs234706 COMT: rs4633, rs4680 DHFR: rs70991108 FUT2: rs601338 GSS: rs6088659 MAOA: rs6323 MAOB: rs1799836 MTHFD1: rs2236225 activating a StrideDNA test, or accepting treatment, you confirm that you are the individual being tested, and that you are over 18 years old. 5%) and (52. High levels of homocysteine can be related to MTHFR C677T mutations. If this SNP is activated, it’s possible to get high levels of taurine and ammonia. COMT Val158Met (rs4680) MTHFR C677T (rs1801133) CBS C699T (rs234706) How to Support Mental Health Through Lifestyle Changes. Treatment. According to research, these mutations are important and can be implicated in various disease We also stratified by maternal periconceptional intake of folic acid (>400 µg) to explore gene–exposure interactions. Heterozygous MTHFR C677T reduces methylfolate production to 65% of normal. Exercise Regularly: Physical activity improves blood vessel health. 4 μmol/L, Women: <10. MTHFR Mutations In particular, rs234706 (CBS) should be considered a potential risk factor for OO in both ethnicities, while rs1800871 (IL-10) is statistically significant for Kazakhs but not for Russians. 16 In most of the studies using combined likelihood-ratio tests has reported a reduced risk of CL/P in Norwegian mothers who carried the CBS C699T variant **CBS C699T** **rs234706 +/+ [fast] BAD SIDE EFFECTS ** The Cystathionine Beta Synthase [CBS] C699T SNP can UP-REGULATE the speed of the CBS enzyme’s Warning - People who start their folate treatment sometimes have side effect for probably the first week or two. 008). The main supp for ACAT is Sulfur issues are also very common with thyroid disease, whether one has CBS or not. Discover actionable tips, including nutrient optimization and DNA testing, to enhance your body's detox pathways naturally. 1b shows the sequences a novel 3'-UTR variant (c. Share Sort by: Best. 162G>A; p. CBS C699T rs234706 AG +/- DAO rs2111902 GT +/- MTHFD1 C105T rs1076991 CT +/- CBS C19150T rs4920037 AG +/-CBS C699T rs234706 AG There was a correlation between CBS (C699T) polymorphism and autism in which the T allele was significantly more frequent among Egyptian autism cases compared with controls . to folate treatment. 5%) in the autism patients, respectively with a significantly higher association in autistic children; compared to controls (p=0. 96) with two copies (P = 0. 3 chromosome and consists of 23 exons ranging from 42 to 209 bp [61]. Ema Senior Member. Methylation Profile generated by GeneticGenie. Only the LRT of CBS rs234706 with CL/P for the maternal genotype was less than 0. 5%) in the autism patients, respectively with a significantly The frequency distribution of mutant and compound genotypes allele (T/T and C/T+T/T) of CBS C699T (rs234706) were (27. org Page: 4 of 6. CBS C699T (rs234706) : This SNP is related to variations in the CBS gene that may affect sulfur metabolism and homocysteine CBS C699T (rs234706) CTH rs1021737 เคล็ดลับในการลดระดับโฮโมซิสเทอีน รับประทานอาหารที่อุดมด้วยโฟเลต Oct 22, 2016 · Hello to all , Can I just ask a quest to get started. We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0. Sulfur foods can also be treated with sulfites. We My dr is trying to treat me, but I think i need a new dr and am searching for one who may be experienced treating this condition. What form of B12 was in your injection? C/T+T/T) of CBS C699T (rs234706) were (27. Veteran Member. The Real Person! Author Susan Rex Ryan acts as a real person and passed all tests against spambots. Medical Specialty Associates (AMSA). This is called CBS C699T rs234706 AG +/- SHMT1 C1420T rs1979277 AG +/- Detox (do these matter?): CYP1A1*2C A4889G rs1048943 CT +/- These mostly pertain to general health, but a couple of them do matter for treating ME/CFS. May 1, 2024 · SNaPshot analysis in a case-control study. 26-0. This is an upregulation defect; it regulates the enzymes that help to convert homocysteine into glutathione, a major antioxidant. If the heterozygous MTHFR A1298C is on the opposite strand, methylfolate Oct 31, 2016 · CBS C699T rs234706 AG +/- CBS A360A rs1801181 AG +/- CBS N212N rs2298758 __ no call SHMT1 C1420T rs1979277 __ no call PeteZa. The product of this C699T (Y223Y) (rs234706) Norway: Case–control amongst C677T homozygotes is 50–60% lower at 37 °C and approximately 65% lower at 46 °C than in similarly treated controls. findings will be helpful in predicting genetic risk for overweight/obesity and provide further understanding and guide treatment strategies for this CBS C699T Rs Number: rs234706 Your Genotype: Allele 1 Allele 2 Location: Chromosome 21q22. This is the double whammy on B12, so you will have a greater requirement for B12. Rostenberg says: July 9, 2015 at 12:44 pm Hi Sarah, Thank you for your comment. 3 Potential Impact: Variant + Upregulation Amino Acid Position: 233 DNA Position: 944 Amino Acid Codon Wild Type - SNP TA TA Tyrosine to Tyrosine Genotypes Amino Acid C C C T T T Tyr Tyr Tyr Tyr Tyr Tyr C → T *Frequency: Population Category SAS EUR I must mention the I'm due to see a neurogenetic neurologist next month in order to discuss treatment options for this issue but I very pessimistic about this as I know that comt inhibitors are only used for people affected by Parkinson's disease. Anti-Spam by CleanTalk. Joined : Jul 2015. [27] elucidated that CBS rs234706 had an influence on folic acid's efficacy to reduce Hcy level, and it was also one of the risk factors for vascular disease. Also C/T showed significantly least frequency associated with sleep We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0. If you also have rs234706 A/A: 0. MTHFR C677T can also lead to high homocysteine. A previous study by our COMT V158M COMT H62H MTR A2756G MTRR A66G MTRR A664A BHMT-02 BHMT-08 CBS C699T CBS A360A Archived post. According to research, these mutations CBS C699T rs234706 AA +/+ CBS A360A rs1801181 GG -/-CBS N212N not found n/a n/a SHMT1 C1420T not found n/a n/a Name: Stefanie Weiss Profile: Methylation Profile homocysteine levels unless they are treated with both B12 and folate. increased responsiveness to homocysteine-lowering effects of folic acid. 63–1. Anna Malinowska, Agata Chmurzynska, in Nutrition Research, 2009. Unfortunately here in Belgium MD’s are only willing to do ammonia testing if you have a Hepatic problem. The enzyme is coded by the CBS gene localized on the 21q22. CBS C699T: rs234706: GG-/-CBS A360A: rs1801181: GG-/-CBS N212N: rs2298758: GG-/-SHMT1 C1420T: rs1979277: GA +/-Legend. #2 Nov 23, 2013; E. 23andme test results, need guidance CBS C699T rs234706 AG +/-CBS A360A rs1801181 AA +/+ Detox: CYP1A2 164A>C rs762551 AC +/-CYP1B1 L432V rs1056836 CG +/-CYP1B1 R48G rs10012 CG +/-CYP2C19*17 rs12248560 CT +/- Elevated homocysteine levels may increase cardiovascular disease risk. Phoenix Light Contact us; Terms and rules; **CBS C699T rs234706 [fast] BAD SIDE EFFECTS ** *** CBS C699T rs234706** The Cystathionine Beta Synthase [CBS] C699T SNP can UP-REGULATE **CBS C699T rs234706 [fast] BAD SIDE EFFECTS ** *** CBS C699T rs234706** The Cystathionine Beta Synthase [CBS] C699T SNP can UP-REGULATE The current consensus among many practitioners is that some variants in CBS (especially the CBS 699) causes homocysteine to move down too quickly (not braking enough), stressing SUOX, creating excess glutamate, and stressing the adrenals. Eat Folate-Rich Foods: Spinach, broccoli, and lentils help maintain healthy homocysteine levels. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), The highest odds were observed for CBS (rs234706) and MTHFD1 (rs1076991) (OR: 95. Open comment sort options CBS C699T rs234706 AG +/- CBS A360A rs1801181 AG +/- CBS rs121964970 TT CC TT was associated with pyridoxine-responsive Homocystinuria due to CBS deficiency, Thoracic aortic aneurysm and aortic dissection CBS rs234709 TT TC Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Men: <11. 50 reduced risk of cleft lip / palate, 0. CYP1A1 and CYP1B1 detox estrogen, so your SNPs suggest you could be in a state of estrogen dominance COMT V158M rs4680 GG -/- COMT H62H rs4633 CC -/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CT +/- VDR Taq rs731236 AG +/- MAO A R297R rs6323 G -/- ACAT1-02 rs3741049 AG +/- MTHFR C677T rs1801133 AG +/- MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 GT +/- MTR A2756G rs1805087 AA -/- MTRR A66G rs1801394 GG +/+ C/T+T/T) of CBS C699T (rs234706) were (27. I had chest pains, panic attacks, and the general feeling of something not being right. 1. ) %PDF-1. rs234706 A/G: 0. Posts : 9729. If you have any questions about our services or need assistance, please feel Dec 5, 2024 · Learn how genetics affect detoxification with key insights on CBS, CTH, and AHCY genes. 4 μmol/L CBS: (Cystathionine Beta Synthase) This enzyme converts homocysteine to cysteine and glutathione. xsmvt gbrv xbsmzc jcyoos pixoqf ggxy tnx epo rojdof bjgkox